周超;杨海华;周丽珍;王碧云;孔敏;陈保富;

• 1:温州医科大学附属台州医院放疗科
• 2:温州医科大学附属台州医院胸外科

摘要(Abstract)：

目的探索局部晚期食管鳞癌新辅助同期放化疗患者生活质量与手术可行性的关系。方法纳入63例局部晚期食管鳞癌患者,在完成新辅助同期放化疗后,43例完成根治性手术,20例未完成手术。患者行新辅助放化疗前及完成放化疗后,分别行欧洲癌症研究治疗组织的生命质量核心问卷(European Organization for Research on Treatment of Cancer Quality of Life Questionnaire-Core 30,EORTC QLQ-C30)及食管癌患者补充量表(Quality of Life Questionnaire-Oesophagus 18,QLQ-OES18)生活质量问卷调查。结果新辅助同期放化疗引起QLQ-C30量表中的躯体功能、认知功能、角色功能及整体生活质量评分下降(均P<0.05),除恶心/呕吐(P=0.786)、失眠(P=0.087)和腹泻(P=0.414)之外的症状评分增加(均P<0.05),QLQ-OES18量表中进食(P=0.021)、梗阻(P=0.014)及口干(P<0.01)评分下降(均P<0.05),其余评分均增加(均P<0.05)。多因素分析显示,治疗前、后食欲丧失评分的变化是手术可行性的唯一预测因子(OR=0.970,95%CI:0.946⁰.995,P=0.020)。结论局部晚期食管鳞癌新辅助同期放化疗会在一定时间内降低患者的生活质量。食欲丧失可考虑用于新辅助放化疗后手术可行性的预测。

关键词(KeyWords)： 食管肿瘤/外科学;食管肿瘤/放射疗法;食管肿瘤/药物疗法;化学疗法,辅助;生活质量;可行性研究

Abstract:

Keywords:

基金项目(Foundation): 浙江省重大科技专项重点社会发展项目(2011C13039-2);; 恩泽医疗中心(集团)科学研究基金(16EZD1)

作者(Authors): 周超;杨海华;周丽珍;王碧云;孔敏;陈保富;

DOI: 10.13267/j.cnki.syzlzz.2018.02.009

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