抗肿瘤药物皮肤不良反应表现
万梦婕;唐梅娟;杨晓阳;
摘要(Abstract):
化疗患者常出现皮肤病变,但许多临床医师常常忽视,有时甚至造成广泛剥脱性皮炎等严重不良反应,严重降低患者生活质量,增加患者治疗风险。本文主要从不同药物角度和皮疹临床表现等方面对化疗药物在皮肤方面的不良反应作一系统综述。
关键词(KeyWords): 化疗;皮肤表现;光过敏;放射性皮炎;手足综合征
基金项目(Foundation):
作者(Authors): 万梦婕;唐梅娟;杨晓阳;
DOI: 10.13267/j.cnki.syzlzz.2021.020
参考文献(References):
- [1] Ali AK, Watson DE. Pharmacovigilance assessment of immune-mediated reactions reported for checkpoint inhibitor cancer immunotherapies[J]. Pharmacotherapy,2017, 37(11):1383-1390.
- [2] Dai J, Belum VR, Wu S, et al. Pigmentary changes in patients treated with targeted anticancer agents:A systematic review and meta-analysis[J]. J Am Acad Dermatol, 2017,77(5):902-910.
- [3] Merlo G, Cozzani E, Canale F, et al. Cutaneous manifestations of hematologic malignancies the experience of an Italian dermatology department[J]. Hematol Oncol, 2019,37(3):285-290.
- [4] Conforti C, Zalaudek I, Vezzoni R, et al. Chemical peeling for acne and melasma:current status and innovations[J].G Ital Dermatol Venereol, 2019, 155(3):280-285.
- [5] Young JWS, Shear NH. Cutaneous drug reactions in the elderly[J]. Drugs Aging, 2017, 34(9):655-672.
- [6] Elsoueidi R, Lander MJ, Richa EM, et al. Single-dose dexamethasone for the prevention of pemetrexed associated cutaneous adverse reactions[J]. J Oncol Pharm Pract,2016, 22(2):271-274.
- [7] Wollina U, Hansel G, Zschuppe E, et al. Pemetrexed-induced pseudocellulitis-a rare cutaneous adverse reaction to multi-targeted antifolate therapy[J]. Georgian Med News, 2017,(267):81-84.
- [8] Kornmehl H, Gorouhi F, Konia T, et al. Generalized fixed drug eruption to piperacillin/tazobactam and review of literature[J]. Dermatol Online J, 2018, 24(4):141-144.
- [9] Zaouak A, Ben Brahim E, Ben Tanfous A, et al. Mucosal fixed drug eruption due to mefenamic acid:Report of a case and a review[J]. Therapie, 2018, 73(5):433-435.
- [10]黎鹏,王炳胜,李永民.抗肿瘤药物引起的手足综合征诊治进展[J].实用肿瘤杂志,2016,31(5):473-477.
- [11] Nikolaou V, Syrigos K, Saif MW. Incidence and implications of chemotherapy related hand-foot syndrome[J].Expert Opin Drug Saf, 2016, 15(12):1625-1633.
- [12] Khandpur S, Porter RM, Boulton SJ, et al. Drug-induced photosensitivity:new insights into pathomechanisms and clinical variation through basic and applied science[J]. Br J Dermatol, 2017, 176(4):902-909.
- [13] Sancar F. First treatment for rare photosensitivity[J].JAMA, 2019, 322(19):1854.
- [14] Borucki R, Werth VP. Cutaneous lupus erythematosus induced by drugs-novel insights[J]. Expert Rev Clin Pharmacol, 2019,13(1):35-42.
- [15] Hegedus F, Mathew LM, Schwartz RA. Radiation dermatitis:an overview[J]. Int J Dermatol, 2017, 56(9):909-914.
- [16] Leventhal J, Young MR. Radiation dermatitis:recognition,prevention, and management[J]. Oncology(Williston Park), 2017, 31(12):885-887, 894-889.
- [17] Nelson CA, Stephen S, Ashchyan HJ, et al. Neutrophilic dermatoses:Pathogenesis, Sweet syndrome, neutrophilic eccrine hidradenitis, and Behcet disease[J]. J Am Acad Dermatol, 2018, 79(6):987-1006.
- [18] Walsh S, Creamer D. Shaping specialist treatment of Stevens-Johnson syndrome/toxic epidermal necrolysis[J]. Br J Dermatol, 2020, 182(3):528-529.
- [19] Guvenir H, Arikoglu T, Vezir E, et al. Clinical phenotypes of severe cutaneous drug hypersensitivity reactions[J].Curr Pharm Des, 2019, 25(36):3840-3854.
- [20] Simeonovski V, Breshkovska H, Duma S, et al. Hydroxyurea associated cutaneous lesions:a case report[J]. Open Access Maced J Med Sci, 2018, 6(8):1458-1461.
- [21]丁林,李青剑,汪颖,等.化疗所致的特殊皮肤改变:病例报道及文献复习[J].岭南现代临床外科,2016, 16(05):564-569.
- [22]王晓杭,陈眉,侯群.神经系统副肿瘤综合征22例临床分析[J].实用肿瘤杂志, 2016, 31(1):59-62.